Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer

The tyrosine kinase (TK) family is an important regulator of signaling pathways that control a variety of physiological and pathological conditions, and a substantial proportion of TK genes are genetically altered in cancer. To clarify the somatic mutation profile of TK genes and discover potential targets for gastric cancer (GC) therapy, we undertook a systematic screening of mutations in the kinase domains of all human TK genes (636 exons of 90 genes) in 17 GC cell lines and 52 microdissected primary GCs with poorly differentiated histology. We identified 26 non-synonymous alterations (22 genes in total) that included 11 sequence alterations in cell lines and 15 somatic mutations in primary tumors. Recurrent mutations were found in four genes including a known oncogene (NTRK3), the Src k… Go to Source

People who read this also read

• Knockouts In Human Cells Point To Pathogenic Targets
  Whitehead researchers have developed a new type of genetic screen for human cells to pinpoint specific genes and proteins used by pathogens, according to their paper in Science. In most human cell cultures genes are present in two copies: one inherited from the father and one from the mother. Gen...
• Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.
  CONCLUSION: The results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations. PMID: 19938198 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG) Go to Source...
• Mental illness gene identified
  Scottish researchers have made a breakthrough as they identified a gene that could help explain the causes of mental illness. The international team of scientists, led by experts at Edinburgh University, discovered the gene ABCA13 that may help create drugs to restore mental health in patients wi...
• Heparanase-specific shRNA: A novel therapeutic strategy in human gastric cancer
  (World Journal of Gastroenterology) A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study showed that stable knockdown of HPA can efficiently decrease the in...
• Idiopathic Granulomatous and Necrotizing Inflammatory Disorders of the Canine Central Nervous System
  Granulomatous meningoencephalomyelitis (GME), necrotizing meningoencephalitis (NME), and necrotizing leukoencephalitis (NLE) are common inflammatory conditions of the canine central nervous system (CNS). While each disease has unique histopathological features, these canine disorders collectively se...