Cholesterol Regulation Alterations Contribute To Intratumoral Androgen Production During Progression To CRPC In A Mouse Xenograft Model

UroToday.com – It is known that in castration-resistant prostate cancer (CRPC) the androgen receptor (AR) is expressed and remains active and prostate cancer (CaP) cells are able to produce their own supply of androgens. These intracrine androgens are synthesized by the increased activity of steroidogenic enzymes that use cholesterol precursors. Cholesterol is a critical cellular molecule that is involved in many cellular processes. Cells obtain cholesterol from both exogenous uptake and endogenous synthesis. In the online edition of Prostate, Dr…

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